This paper highlights some of the major and effective ICT innovations and practices in dealing with COVID-19 in the following sectors: Healthcare, Communication with Communities, Education, Business, and Infrastructure. COVID-19 related ICT-centered interventions or trends are categorized using a newly introduced multi-dimensional evaluation framework, the 4 A-I model, which focuses on the awareness, availability, accessibility and affordability of digital technologies. The 4 A-I framework assisted in analyzing the overall effectiveness, challenges, and emerging opportunities of ICT applications for combating COVID-19 across the Asia-Pacific region. It furthermore helped to analyze the level of inclusiveness, interoperability, inter-governmental co-operations, and robustness of relevant ICT infrastructures and applications.